简历：
2015-今 bevictor伟德，特聘研究员，教授，博士生导师，研究方向：生物正交化学，光点击化学
2014-2015 年研究助理教授，专业，化员工物学，研究方向：生物正交化学，光点击化学；完成单位：美国纽约州立大学布法罗分校化学系
2009-2014 年博士后研究助理，专业，化员工物学，研究方向：生物正交化学，光点击化学；完成单位：美国纽约州立大学布法罗分校化学系；合作导师：Qing Lin 教授
学习经历：
2004-2009年 Ph.D. 理学博士学位，专业: 有机化学; 研究方向: 不对称催化化；授予学校：伟德bevictor中文版; 导师：冯小明 院士
2000-2004 年 B.S. 理学学士学位，专业: 应用化学；授予学校：伟德bevictor中文版;
工作经历：
2015-今 bevictor伟德，特聘研究员，教授，博士生导师，研究方向：生物正交化学，光点击化学
2014-2015 年研究助理教授，专业，化员工物学，研究方向：生物正交化学，光点击化学；完成单位：美国纽约州立大学布法罗分校化学系
2009-2014 年博士后研究助理，专业，化员工物学，研究方向：生物正交化学，光点击化学；完成单位：美国纽约州立大学布法罗分校化学系；合作导师：Qing Lin 教授
主要研究方向：有机合成化学；“光点击”化学；活性分子的生物合成；生物正交化学；生物定向进化；
点击化学("click" chemistry)是诺贝尔化学奖得主Sharpless教授在2001年提出的一种快速共价偶联策略。 而"光点击"与"点击"化学的关系是青出于蓝，胜于蓝。它继承了点击反应的优点，同时也是受光激发，实现时空控制构建共价连接的化学利器。 在“光点击”化学反应中，利用直接光转化或者光催化策略，实现生物正交偶联的精准光控，达到亚细胞/单分子级别的时空精准度。采用环张力环融合策略，将“光点击”反应提高10倍以上的反应动力学。利用课题组原创的环偶氮亲偶极体，首次合成DBTD丙氨酸作为非天然氨基酸衍生物，并将其用于遗传密码扩展（GCE）编载重组蛋白质表达，实现超快速活体内蛋白质特定残基的荧光标记。这一系列创新研究，将推进“光点击”生物正交反应在活体动物中的靶标分子的跟踪和操控研究，起到了中流砥柱承前启后的作用。
欢迎有志于在生物正交化化学研究国际前沿做研究工作的员工到我实验室来从事科研探索！我们欢迎您投入到 化学与分子生物学交叉学科的研究中，扩展视野。
可选研究方向选择：
化员工物学，生物正交化学
有机合成化学, 光控(光催化)化学合成
生物分子的定向进化
主要工作业绩：
余志鹏博士毕业于伟德bevictor中文版，师从冯小明院士。后赴美国纽约州立大学布法罗分校化学系开展博士后研究工作，后升任美国纽约州立大学布法罗分校化学系研究助理教授。在入职伟德bevictor中文版以来，致力于研究以“光点击化学”为基础的生物正交化学以及其在活体生命环境中的外源性化学功能的引入及其相关的应用，致力于开拓化员工物学前沿的研究方向的教学和科研工作。
主要开展前沿的“光点击”化学反应的原创性开发，以及其在可光控的分子生物学探针研发，原生活体中生物分子的生物正交标记、示踪（基于超高效、超高选择性的有机化学反应为基础）中的突破性创新。研究高度生物兼容且精准可控的超快共价偶联（脱保护）反应、实现超高化学专一性的生物正交偶联反应策略。余志鹏课题组已经研发出国际前沿的两代、三类型的“光点击”反应，其可在高度拥挤的活体细胞浆质内实现选择性的生物大分子修饰和功能调控，对生物分子添加外源性功能性残基，扩展活体生命系统的功能。该研究不仅仅可以通过化学功能团的载入实现对特定生物代谢，基因的调控，细胞的信号传导等等生物过程的干预和操控，同时也是精准药物发现和原位构建3D生物功能材料的基础化学利器。
建立了以介离子“悉尼酮”为基础的“光点击”化学新方法，丰富了“光点击”化学前沿工具库，达成可控、高效构建共价键，以及协同断键释放功能。实现其在活体中原位精确标记生物分子以及药物分子释放的诊疗一体化交叉应用。原创发现一类T-型“光开关”环偶氮分子，其作为独特的亲偶极体与悉尼酮配套组建新一类“光点击”反应系统，验证了这一全新生物正交报告基的全能性，提出从光能利用的角度来突破光点击化学发展的概念。定向进化MmPylRS（吡咯赖氨酸tRNA合成酶），创新发展环偶氮非天然氨基酸的遗传密码扩展系统（GCE），实现活细胞中蛋白高精度示踪以及光控基因表达的新思路。
主要奖励和荣誉：
2021 第十三批 四川省学术和技术学术带头人后备人选
2019 Thieme Chemistry Journals Award (由Thieme数据库三大著名有机化学期刊Synthesis、Synlett和Synfact的学术编委会在全球范围遴选，授予在有机化学研究领域取得出色成果，并拥有巨大发展潜力的青年化学家)
2016 入选四川省高层次人才引进计划青年项目目
2015 入选国家级四青人才项目
2008 宝钢教育奖, 宝钢优秀员工特等奖
代表性成果 （获奖成果、专著、论文、专利）：
1. 通讯作者发表的研究论文: Fuqiang Hu, Cefei Zhang, Zhihao Liu, Xinyu Xie, Xiaohu Zhao, Yanju Luo, Jielin Fu, Baolin Li, Changwei Hu, Zhishan Su* and Zhipeng Yu,* titled "Photoswitchable and long-lived seven-membered cyclic singlet diradicals for the bioorthogonal photoclick reaction" Chem. Sci., 2023, 14, 13254–13264.
2. 唯一通讯作者发表的研究论文: Jielin Fu, Sitong Li, Lijun Deng, Xiaohu Zhao and Zhipeng Yu,* titled "A genetically encodable and fluorogenic photo-crosslinker via photo-induced defluorination acyl fluoride exchange" Chem. Commun., 2023, 59, 11073–11076.
3. 通讯作者发表的研究论文: Lijun Deng, Cefei Zhang, Baolin Li, Jielin Fu, Zhong Zhang, Sitong Li, Xiaohu Zhao, Zhishan Su, Changwei Hu,* and Zhipeng Yu,* titled "Photo-induced defluorination acyl fluoride exchange as a fluorogenic photo-click reaction for photo-affinity labeling" Chem. Sci., 2023, 14, 3630–3641.
4. 唯一通讯作者发表的研究论文: Xinyu Xie, Fuqiang Hu, Yuqiao Zhou, Zhihao Liu, Xin Shen, Jielin Fu, Xiaohu Zhao, and Zhipeng Yu,* titled "Photoswitchable Oxidopyrylium Ylide for Photoclick Reaction with High Spatiotemporal Precision: A Dynamic Switching Strategy to Compensate for Molecular Diffusion" Angew. Chem. Int. Ed., 2023, 62, e202300034.
5. 唯一通讯作者发表的研究论文: Tingting Zheng, Jielin Fu, Qin Xiong, Xin Shen, Baolin Li, Xiaohu Zhao and Zhipeng Yu,* titled "Photo-regulated genetic encoding of dibenzo[c,g][1,2]diazocine on proteins via configuration switching" Chem. Commun., 2023, 59, 1201–1204.
6. 通讯作者发表的研究论文: Xin Shen, Cefei Zhang, Fengying Lan, Zhishan Su, Yuanqin Zheng, Tingting Zheng, Qin Xiong, Xinyu Xie, Guangxi Du, Xiaohu Zhao, Changwei Hu,* Pengchi Deng,* and Zhipeng Yu,* titled "Dibenzo[b,f][1,4,5]chalcogenadiazepine Photoswitches: Conversion of Excitation Energy into Ring Strain" Angew. Chem. Int. Ed. 2022, e202209441.
7. 唯一通讯作者发表的研究论文: Qin Xiong, Tingting Zheng, Xin Shen, Baolin Li, Jielin Fu, Xiaohu Zhao, Chunxia Wang and Zhipeng Yu,* titled "Expanding the functionality of proteins with genetically encoded dibenzo[b,f][1,4,5] thiadiazepine: a photo-transducer for photo-click decoration" Chem. Sci., 2022, 13, 3571-3581.
8. 通讯作者发表的研究论文: Hui Liu, Tingting Zheng, Yuanqin Zheng, Baolin Li, Xinyu Xie, Xin Shen, Xiaohu Zhao,* and Zhipeng Yu,* titled "Visible-light induced photo-click and release strategy between monoarylsydnone and phenoxylfumarate" Chem. Commun., 2021, 57, 8135-8138.
9. 通讯作者发表的研究论文: Yuanqin Zheng, Yuqiao Zhou, Shichao Jiang, Xinyu Xie, Guangxi Du, Xin Shen, Xiaohu Zhao* and Zhipeng Yu,* titled "Rapid construction of bicyclic triazoline skeletons with dual-state emission via cycloaddition reaction of 4-phenyl-1,2,4-triazoline-3,5-dione with vinyl azides" Org. Chem. Front., 2023, 10, 1495-1504.
10. 通讯作者发表的研究论文: Yuanqin Zheng, Yuqiao Zhou, Yan Zhang, Pengchi Deng, Xiaohu Zhao, Shichao Jiang, Guangxi Du, Xin Shen, Xinyu Xie, Zhishan Su,* and Zhipeng Yu,* titled "Water-Involved Ring-Opening of 4-Phenyl-1,2,4-triazoline-3,5-dione for “Photo-Clicked” Access to Carbamoyl Formazan Photoswitches In Situ" Chem Asian J., 2022, 17, e202101239.
11. 通讯作者发表的研究论文: Jingshuo Gao, Qin Xiong, Xueting Wu, Jiajie Deng, Xiaocui Zhang, Xiaohu Zhao, Pengchi Deng*, Zhipeng Yu,* titled "Direct ring-strain loading for visible-light accelerated bioorthogonal ligation via diarylsydnone-dibenzo[b,f][1,4,5]thiadiazepine photo-click reactions" Commun. Chem., 2020, 3, 29.
12. 独立通讯作者发表的研究论文: Shichao Jiang, Xueting Wu, Hui Liu, Jiajie Deng, Xiaocui Zhang, Zhuojun Yao, Yuanqin Zheng, Bo Li, and Zhipeng Yu,* titled "Ring-Strain-Promoted Ultrafast Diaryltetrazole–Alkyne Photoclick Reactions Triggered by Visible Light" ChemPhotoChem, 2020, 4, 327–331.
13. 独立通讯作者发表的研究论文: Xiaocui Zhang, Xueting Wu, Shichao Jiang, Jingshuo Gao, Zhuojun Yao, Jiajie Deng, Linmeng Zhang and Zhipeng Yu,* titled "Photo-accelerated "click" reaction between diarylsydnones and ring-strained alkynes for bioorthogonal ligation" Chem. Commun., 2019, 55, 7187–7190.
14. 独立通讯作者发表的研究论文: Linmeng Zhang, Xiaocui Zhang, Zhuojun Yao, Shichao Jiang, Jiajie Deng, Bo Li, and Zhipeng Yu,* titled "Discovery of Fluorogenic Diarylsydnone-Alkene Photoligation: Conversion of ortho-Dual-Twisted Diarylsydnones into Planar Pyrazolines" J. Am. Chem. Soc., 2018, 140 (24), pp 7390–7394.
15. 合作发表的研究论文: Carlo P. Ramil, Maoqing Dong, Peng An, Tracey M. Lewandowski, Zhipeng Yu, Laurence J. Miller,* and Qing Lin,* titled "Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells" J. Am. Chem. Soc., 2017, 139, 13376–13386.
16. 合作发表的研究论文: Yulin Tian, Marco Paolo Jacinto, Yu Zeng, Zhipeng Yu, Jun Qu, Wenshe R. Liu,* and Qing Lin,* titled "Genetically Encoded 2-Aryl-5-carboxytetrazoles for Site-Selective Protein Photo-Cross-Linking " J. Am. Chem. Soc., 2017, 139, 6078–6081.
17. 合作发表的研究论文: Carlo P. Ramil, Peng An, Zhipeng Yu , and Qing Lin*, titled "Sequence-specific 2-cyanobenzothiazole ligation " J. Am. Chem. Soc., 2016 , 138, 5499–5502.
18. 以第一作者发表的研究论文: Zhipeng Yu and Qing Lin*, titled "Design of Spiro[2.3]hex-1-ene, a Genetically Encodable Double-Strained Alkene for Superfast Photoclick Chemistry" J. Am. Chem. Soc., 2014, 136, 4153–4156.
19. 以第一作者发表的研究论文: Zhipeng Yu, Tymish Y. Ohulchanskyy, Peng An, Paras N. Prasad, and Qing Lin,* titled "Fluorogenic, Two-Photon-Triggered Photoclick Chemistry in Live Mammalian Cells" J. Am. Chem. Soc., 2013, 135, 16766–16769.
20. 以第一作者发表的研究论文: Zhipeng Yu, Yanchao Pan, Zhiyong Wang, Jiangyun Wang,* Qing Lin,* titled "Genetically Encoded Cyclopropene Directs Rapid, Photoclick-Chemistry-Mediated Protein Labeling in Mammalian Cells" Angew. Chem. Int. Ed., 2012, 51, 10600-10604.
21. 8. 以第一作者发表的研究论文: Zhipeng Yu, Lok Yin Ho, and Qing Lin*, titled "Rapid, Photoactivatable Turn-On Fluorescent Probes Based on an Intramolecular Photo click Reaction" J. Am. Chem. Soc., 2011, 133, 11912–11915.
22. 以第一作者发表的研究论文: Zhipeng Yu, Lok Yin Ho, Zhiyong Wang, Qing Lin*, titled "Discovery of new photoactivatable diaryltetrazoles for photoclick chemistry via ‘scaffold hopping’" Bioorg. Med. Chem. Lett., 2011, 21, 5033-5036.
23. 以第一作者发表的研究论文: Zhipeng Yu, Reyna K. V. Lim, Qing Lin*, titled "Synthesis of Macrocyclic Tetrazoles for Rapid Photoinduced Bioorthogonal 1,3-Dipolar Cycloaddition Reactions" Chem. Eur. J., 2010, 16, 13325-13329.
24. 合作发表的研究论文: Peng An, Zhipeng Yu and Qing Lin*, titled "Design of oligothiophene-based tetrazoles for laser-triggered photoclick chemistry in living cells" Chem. Commun., 2013, 49, 9920-9922.
25. 合作发表的研究论文: Peng An, Zhipeng Yu and Qing Lin*, titled "Design and Synthesis of Laser-Activatable Tetrazoles for a Fast and Fluorogenic Red-Emitting 1,3-Dipolar Cycloaddition Reaction" Org. Lett., 2013, 15, 5496–5499.
26. 合作发表的研究论文: Jiangyun Wang, Wei Zhang, Wenjiao Song, Yizhong Wang, Zhipeng Yu, Jiasong Li, Minhao Wu, Lin Wang, Jianye Zang, and Qing Lin*, titled "A Biosynthetic Route to Photoclick Chemistry on Proteins" J. Am. Chem. Soc., 2010, 132, 14812–14818.
27. 合作发表的研究论文: Wenjiao Song, Yizhong Wang, Zhipeng Yu, Claudia I. Rivera Vera, Jun Qu, and Qing Lin*, titled "A Metabolic Alkene Reporter for Spatiotemporally Controlled Imaging of Newly Synthesized Proteins in Mammalian Cells" ACS Chem. Biol., 2010, 5, 875–885 (Cover Article).
28. 合作发表的研究论文: Wenjiao Song, Zhipeng Yu, Michael M. Madden and Qing Lin*, titled "A bioorthogonal chemistry strategy for probing protein lipidation in live cells" Mol. BioSyst., 2010, 6, 1576-1578.
29. 以第一作者发表的研究论文: Zhipeng Yu, Xiaohua Liu, Lin Zhou, Lili Lin, Xiaoming Feng*, titled "Bifunctional Guanidine via an Amino Amide Skeleton for Asymmetric Michael Reactions of β-Ketoesters with Nitroolefins: A Concise Synthesis of Bicyclic β-Amino Acids" Angew. Chem. Int. Ed. 2009, 48, 5195-5198.
30. 合作发表的研究论文: Shao-Liang Zheng, Yizhong Wang, Zhipeng Yu, Qing Lin*, and Philip Coppens*, titled "Direct Observation of a Photoinduced Nonstabilized Nitrile Imine Structure in the Solid State" J. Am. Chem. Soc. 2009, 131, 18036-18037.
31. 以第一作者发表的研究论文: Zhipeng Yu, Xiaohua Liu, Zhenhua Dong, Mingsheng Xie, and Xiaoming Feng*, titled "An N,N’-Dioxide/In(OTf)3 Catalyst for the Asymmetric Hetero-Diels-Alder Reaction Between Danishefsky’s Dienes and Aldehydes: Application in the Total Synthesis of Triketide". Angew. Chem. Int. Ed. 2008, 47, 1308-1311.
32. 合作发表的研究论文: Bo Gao, Zhipeng Yu, Zhengyan Fu and Xiaoming Feng*, titled "A Convenient and Versatile Approach to 2,3-dihydro-4H-pyran-4-ones via Tandem Aldol Reaction-conjugate Addition", Tetrahedron Letters. 2006, 47, 1537-1539.
33. 合作发表的研究论文: Bo Gao, Zhengyan Fu, Zhipeng Yu, Lan Yu, Yaozong Huang and Xiaoming Feng*, titled "Highly enantioselective hetero-Diels–Alder reaction between trans-1-methoxy-2-methyl-3-trimethyl-siloxybuta-1,3-diene and aldehydes catalyzed by (R)- BINOL-Ti(IV) complex", Tetrahedron. 2005, 61, 5822-5830.
34. 合作发表的研究论文: Ke Cheng, Baiqing Zeng, Zhipeng Yu, Bo Gao, Xiaoming Feng*, titled "A Mild and Efficient Synthesis of 2,5-disubstituted 2,3-Dihydro-4-pyridones Catalyzed by Yb(OTf)3", Synlett. 2005, 1018-1020.
35. 合作发表的研究论文: Zhengyan Fu, Bo Gao, Zhipeng Yu, Lan Yu, Yaozhong Huang, Xiaoming Feng,* Guolin Zhang,* titled "An Efficient and Enantioselective Approach to 2,5-Disubstituted Dihyropyrones", Synlett. 2004, 1772-1775.
