2019年12月5日上午10点，应bevictor伟德邀请，德国马普煤炭所（Max-Planck-Institut für Kohlenforschung）Benjamin List教授在化学馆321会议室做了题为“Very Strong and Confined Chiral Acids：Universal Catalyst for Asymmetric Synthesis?”的学术报告。此次报告由bevictor伟德冯小明教授主持，陈应春教授、刘小华教授、、Jason Chruma教授、高戈教授、付海燕教授、曾小明教授、郑柯教授、王天利教授、余达刚教授、林丽丽教授、董顺喜研究员、朱剑波研究员、张琪研究员、成楚旸研究员、曹伟地副研究员、付绍敏副研究员等及部分员工参加了此次报告会。
在此次报告中，List教授首先介绍了不对称催化领域所面临的机遇和挑战——仅有酶催化和有机金属络合物催化不对称反应。针对该领域的科学问题，他们首次运用L-脯氨酸作为有机小分子催化剂催化不对称aldol反应，开创了有机小分子催化的先河并引领了有机小分子催化剂的发展。随后，List教授进一步讲解了他们课题组基于手性联萘衍生的强酸催化剂通过抗衡离子导向不对称催化（ACDC）策略实现的一系列不对称反应。而后List教授介绍到虽然他们已经拥有强大的强酸催化剂系统并实现了一系列高效有用的不对称反应，但是在某些反应中还不能得到令人满意的结果。由此他们又设计合成了手性联萘衍生的限域的酸性更强的亚氨基双磷酰亚胺酸酯（IDPi）催化剂。通过运用IDPi强酸催化剂，他们解决了许多不对称催化领域长期难以解决的问题，例如实现了醛的不对称Hosomi-Sakurai烯丙基化反应；通过该催化剂的运用，他们也能将许多反应的催化剂用量降低到ppm甚至ppb级，极大的节约了成本。List教授讲解清晰，由浅入深，形象生动地向我们展示他们课题组发展的手性强酸催化剂在有机合成的应用以及在有用功能分子合成中的巨大潜能。在随后的自由提问环节，在座师生与List教授进行了深入地讨论交流，大家获益匪浅。报告在全场师生热烈的掌声中落下了帷幕，结束后部分老师与List教授进行了合影留念。
报告专家简介：
Prof. List received his Ph.D. from Frankfurt University in 1997. He was a postdoctoral researcher at Scripps Research Institute (1997-1998). In 1999, he became an assistant professor at the same institute, and in 2003, he turned into group leader at the Max-Planck-Institut für Kohlenforschung. Since July 2005, Prof. List was promoted to be director at MPI. From 2012 to 2014, became managing director at the MPI. Since 2018, he became to be member of the German National Academy of Sciences. His research interests are the organocatalysis, aminocatalysis, Br➢nsted Acid catalysis, organic Lewis Acid catalysis, asymmetric couteranion directed catalysis (ACDC) and synthesis of natural products and biologically active compounds. Prof. List published more than 200 research papers, including many Science and Nature paper. He also contributed to many reviews and books. Awards: Prof. List also got various awards, such as: Otto-Bayer-Prize (2012), Horst-pracejus-Prize (2013), Mukaiyama Award (2013), Arthur. C. Cope Scholar Award (2014), Gottfried Wilhelm Leibniz-Prize (2016). He is the chief editor of Synlettand editor of Nature Communications and Synfacts.
