RESEARCH INTERESTS:
Professor Chen’s research areas include the systheses of water-soluble trasition metal phosphine complexes and their application in aqueous/organic biphasic catalytic system, the application of chiral catalysts in asymmetric syntheses, green industry production of fine chemicals and petrochemical industry production, and C-C coupling reaction. The systheses of water-soluble rhodium phosphine complexes and their application in aqueous/organic biphasic hydroformylation have owned the independent knowledge authority of our country. The development new catalyst has showed great reaction activity and selectivity in hydroformylation, which has a crucial value in green chemitry research and is supported by National Key Basic Research Program of China.
EDUCATION AND ACADEMIC CAREER:
1979/9–1983/7，College of Chemistry，Sichuan University，Bachelor
1991/9–1994/7，College of Chemistry，Sichuan University，Master., Tutor: Li Xianjun
1996/9–1999/7, School of Chemistry, Sichuan University, Ph. D., Tutor: Li Xianjun
1999/12-2000/12, Department of Applied Biology and Chemical Science and Technology, Hong Kong Polytechnic University, postdoctoral, under Academician Chen Xinzi.
2005-2010, Professor of Chemistry College of Sichuan University, doctoral supervisor, Director of Organic Teaching and Research Department of Chemistry College of Sichuan University, Vice Dean of Chemistry College, Director of Chemistry Experimental Teaching Center of Sichuan University. Ministry of Education Science and Technology Award Evaluation expert
2011 to date, Director, Committee of Professors, School of Chemistry, Sichuan University
2016 to date, Member of the Committee of Laboratory Safety Experts of the Ministry of Education
HONORS AND AWARDS:
Academic and Technical Leader of Sichuan Province
Win the First Prize of Scientific and Technological Progress of Sinopec Group and Second Prize of Scientific and Technological Progress of Xinjiang Uygur Autonomous Region.
SELECTITED PUBLICATIONS:
1. Yi, J.; Zhao, J.; Tang, S.; Yang, C.; Fu, H.; Zheng, X. L.*; Chen, H.*; Yuan, M.; Li, R. A novel biphasic and recyclable system based on formamide for the hydroformylation of long-chain alkenes with water-soluble phosphine rhodium catalyst. Mol Catal 2021, 505, 111502.
2. Zhao, J.; Yi, J.; Yang, C.; Wan, K.; Duan, X.; Tang, S.; Fu, H.; Zheng, X. L.*; Yuan, M.*; Li, R.; Chen, H. A Novel Strategy of Homogeneous Catalysis and Highly Efficient Recycling of Aqueous Catalyst for the hydroformylation of Higher Olefins Based on a Simple Methanol/Water Mixed Solvent. Catal Lett 2020.
3. Wan, K.; Zhao, J.; Qin, S.; Zheng, X. L.*; Fu, H.; Li, R.; Chen, H.*; Yang, J.; Yang, C. Linear‐selective hydroformylation of vinyl ether using Rh (acac)(2,2′‐ bis{(di[1H‐indol‐1‐yl]phosphanyl)ox1,1′‐binaphthalene) – Possible way to synthesize 1,3‐propanediol. Appl Organometal Chem 2020.
4. Li, S.; Li, W.-J.; Yang, X.; Sun, R.; Tang, J.; Zheng, X.-L.; Yuan, M.-L.; Li, R.-X.; Chen, H.; Fu, H.-Y. *, Selective direct C–H polyfluoroarylation of electron-deficient N-heterocyclic compounds. Organic Chemistry Frontiers 2020, 7 (23), 3887-3895;
5. Li, W.; Tang, J.; Li, S.; Zheng, X.; Yuan, M.; Xu, B.; Jiang, W.; Haiyan, F. *; Li, R.; Chen, H., Stereodivergent Synthesis of Alkenylpyridines via Pd/Cu Catalyzed C-H Alkenylation of Pyridinium Salts with Alkynes. Organic letters 2020, 22 (20), 7814-7819;
6. Nie, X.; Zheng, Y.; Ji, L.; Fu, H. *; Chen, H.; Li, R. *, Acceptorless dehydrogenation of amines to nitriles catalyzed by N-heterocyclic carbene-nitrogen-phosphine chelated bimetallic ruthenium (II) complex. Journal of Catalysis 2020, 391, 378-385;
7. Xu, K.; Li, W.; Sun, R.; Luo, L.; Chen, X.; Zhang, C.; Zheng, X.; Yuan, M.; Fu, H. *; Li, R.; Chen, H., Synthesis of 2-Formylpyrroles from Pyridinium Iodide Salts. Organic letters 2020, 22 (15), 6107-6111;
8. Yang, X.; Sun, R.; Li, S.; Zheng, X.; Yuan, M.; Xu, B.; Jiang, W.; Chen, H.; Fu, H. *; Li, R. *, Regioselective Direct C-H Trifluoromethylation of Pyridine. Organic letters 2020, 22 (18), 7108-7112
9. Zheng, Y.; Nie, X.; Long, Y.; Ji, L.; Fu, H*.; Zheng, X.; Chen, H.; Li, R*. Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines. Chem Commun 2019, 55,12384-12387
10. Liu, H. M.; Jian, L.; Li, C.; Zhang, C. C.; Fu, H. Y.*; Zheng, X. L.; Chen, H.; Li, R. X.*, Dehydrogenation of Alcohols to Carboxylic Acid Catalyzed by in Situ-Generated Facial Ruthenium-CPP Complex. J Org Chem, 2019. 84(14): p. 9151-9160.
11. Li, W.; Liu, H.; Chen, X.; Li, S.; Zheng, R.; Zhang, C.; Zheng, X.; Yuan, M.; Li, R.; Fu, H.*; Chen, H*. Palladium-catalyzed direct ortho-alkynylation of aryl acetamides with low catalyst loading. Tetrahedron Letters. 2019, 60, 1875
12. Yang, X.; Sun, R.; Zhang, C.; Zheng, X.*; Yuan, M.; Fu, H.*; Li, R.; Chen, H., Iridium-Catalyzed Benzylamine C-H Alkenylation Enabled by Pentafluorobenzoyl as the Directing Group. Org Lett, 2019. 21(4): p. 1002-1006.
13. Hao, T. T.; Liang, H. R.; Ou-Yang, Y. H.; Yin, C. Z.; Zheng, X. L.; Yuan, M. L.; Li, R. X.; Fu, H. Y.*; Chen, H.*, Palladium-Catalyzed Domino Reaction for Stereoselective Synthesis of Multisubstituted Olefins: Construction of Blue Luminogens. J Org Chem, 2018. 83(8): p. 4441-4454.
14. Jia, F.; Yin, C.; Zeng, Y.; Sun, R.; Ge, Y. C.; Xu, D.; Li, R.; Chen, H.; Zhang, C*.; Fu, H.*, Mechanism of Direct C-H Arylation of Pyridine via a Transient Activator Strategy: A Combined Computational and Experimental Study. J Org Chem, 2018. 83(17): p. 10389-10397.
15. Sun, R.; Yang, X.; Chen, X.; Zhang, C.; Zhao, X.; Wang, X.; Zheng, X.; Yuan, M.; Fu, H.*; Li, R.; Chen, H.*, Rh(III)-Catalyzed [4 + 2] Self-Annulation of N-Vinylarylamides. Org Lett, 2018. 20(21): p. 6755-6759.
16. Yin, C.; Zhong, K.; Li, W.; Yang, X.; Sun, R.; Zhang, C.; Zheng, X.; Yuan, M.; Li, R.; Lan, Y.; Fu, H*.; Chen, H*, C6-Selective Direct Arylation of 2-Phenylpyridine via an Activated N-methylpyridinium Salt: A Combined Experimental and Theoretical Study. Advanced Synthesis & Catalysis, 2018. 360(20): p. 3990-3998
17. Zeng, Y.; Zhang, C.; Yin, C.; Sun, M.; Fu, H.*; Zheng, X.; Yuan, M.; Li, R.; Chen, H. *, Direct C-H Functionalization of Pyridine via a Transient Activator Strategy: Synthesis of 2,6-Diarylpyridines. Org Lett 2017, 19 (8), 1970-1973.
18. Huang, J.; Wang, W.; He, H.-Y.; Jian, L.; Fu, H.-Y. *; Zheng, X.-L.; Chen, H.; Li, R.-X.*, An Approach to the Synthesis of 1-Propenylnaphthols and 3-Arylnaphtho[2,1-b]furans. The Journal of Organic Chemistry 2017, 82 (5), 2523-2534.
19. Fu, H.; Shen, P. X.; He, J.; Zhang, F.; Li, S.; Wang, P.; Liu, T.; Yu, J. Q., Ligand-Enabled Alkynylation of C(sp3 )-H Bonds with Palladium(II) Catalysts. Angewandte Chemie 2017, 56 (7), 1873-1876.
20. Li, W.; Yin, C.; Yang, X.; Liu, H.; Zheng, X.; Yuan, M.; Li, R.; Fu, H.; Chen, H.Cu(ii)-Mediated keto C(sp(3))-H bond alpha-acyloxylation of N,N-dialkylamides with aromatic carboxylic acids. Org Biomol Chem, 2017. 15(36): p. 7594-7599
21. Liu, H.; Han, W.; Li, C.; Ma, Z.; Li, R.; Zheng, X.; Fu, H. *; Chen, H. *, Practical Synthesis of Phenanthridinones by Palladium-Catalyzed One-Pot C-C and C-N Coupling Reaction: Extending the Substrate Scope too-Chlorobenzamides. European Journal of Organic Chemistry 2016, 2016 (2), 389-393.
22. Wang, W.; Huang, J.; Zhou, R.; Jiang, Z.-J.; Fu, H.-Y. *; Zheng, X.-L.; Chen, H.; Li, R.-X.*, A Simple and Efficient Access to Naphtho[b]furans by Claisen Rearrangement/Cyclization of Bromonaphthyl 3-Phenylallyl Ethers. Advanced Synthesis & Catalysis 2015, 357 (11), 2442-2446.
23. Ma, Z.; Liu, H.; Zhang, C.; Zheng, X.; Yuan, M.; Fu, H. *; Li, R.; Chen, H. *, One-Pot Synthesis of Symmetrical 2,6-DiarylpyridinesviaPalladium/Copper-Catalyzed Sequential Decarboxylative and Direct CH Arylation. Advanced Synthesis & Catalysis 2015, 357 (6), 1143-1148.
24. Ge, Y.; Cheng, Y.; Fu, H. *; Zheng, X.; Li, R.; Chen, H. *; Li, X., Suzuki-Miyaura cross-coupling reaction catalyzed by a highly stable Pd(P-Phos)Cl-2 complex at room temperature under air. Chinese Journal of Catalysis 2013, 34 (9), 1667-1673.
25. Fu, H.; Chen, H.; Doucet, H., Palladium-catalyzed selective decarboxylative coupling reaction versus direct C?H arylation for arylation of heteroaromatics. Applied Organometallic Chemistry 2013, 27 (10), 595-600.
26. Fu, H. Y.; Zhao, L.; Bruneau, C.; Doucet, H., Palladium-Catalysed Direct Heteroarylations of Heteroaromatics Using Esters as Blocking Groups at C2 of Bromofuran and Bromothiophene Derivatives: A One-Step Access to Biheteroaryls. Synlett 2012, (14), 2077-2082.
27. Fu, H. Y.; Chen, L.; Doucet, H., Phosphine-Free Palladium-Catalyzed Direct Arylation of Imidazo 1,2-a pyridines with Aryl Bromides at Low Catalyst Loading. Journal of Organic Chemistry 2012, 77 (9), 4473-4478.
28. Pi, X.; Zhou, Y.; Zhou, L.; Yuan, M.; Li, R.; Fu, H. *; Chen, H.*, Dicyclopentadiene Hydroformylation in an Aqueous/Organic Two Phase System in the Presence of a Cationic Surfactant. Chinese Journal of Catalysis 2011, 32 (4), 566-571.
29. Liu, H.; Yuan, M.; Guo, C.; Li, R.; Fu, H. *; Chen, H. *; Li, X., Selective Hydrogenation of Cinnamaldehyde to Cinnamyl Alcohol over Ru/ZrO2 center dot xH(2)O Catalyst. Chinese Journal of Catalysis 2011, 32 (7), 1256-1261.
30. Fu, H. Y.; Doucet, H., Methyl 2-Furoate: An Alternative Reagent to Furan for Palladium-Catalysed Direct Arylation. European Journal of Organic Chemistry 2011, (35), 7163-7173.
31. Fu, H.; Yuan, M.; Chen, H.; Li, R.; Li, X., Progress of Olefin Hydroformylation Catalyzed by Water-Soluble Rhodium-Phosphine Complexes. Chinese Journal of Catalysis 2010, 31 (3), 251-260.
32. Mao, H.; Fu, H. *; Chen, H. *; Li, R.; Li, X., Synergistic Effect of TPPTS and TPPDS on the Regioselectivity for 1-Decene Hydroaminomethylation in a Two-Phase Catalytic System. Chinese Journal of Catalysis 2009, 30 (12), 1192-1196.
33. Fu, H.; Li, M.; Mao, H.; Lin, Q.; Yuan, M.; Li, X.; Chen, H., Aqueous biphasic catalytic hydroformylation of higher olefins: Promotion effect of cationic gemini and trimeric surfactants. Catalysis Communications 2008, 9 (7), 1539-1544.
34. Fu, H.; Li, M.; Chen, J.; Zhang, R.; Jiang, W.; Yuan, M.; Chen, H.; Li, X., Application of a new amphiphilic phosphine in the aqueous biphasic catalytic hydroformylation of long chain olefins. Journal of Molecular Catalysis a-Chemical 2008, 292 (1-2), 21-27.
35. Fu, H.; Li, M.; Chen, H.; Li, X., Higher olefin hydroformylation in organic/aqueous biphasic system accelerated by double long-chain cationic surfactants. Journal of Molecular Catalysis a-Chemical 2006, 259 (1-2), 156-160.
36. Fu, H.; Guo, Y.; Lin, Q.; Chen, H.; Li, X., Cocatalytic effect of new surface-active phosphine in long-chain olefin hydroformylation. Chinese Journal of Catalysis 2006, 27 (12), 1053-1058.
